DAVID Jean-Philippe

• 2022 :

  Directeur de Recherche CNRS (DR2), LECA Grenoble

• 2017 - 2021 :

  Membre élu du Comité National de la Recherches Scientifique (CNRS) (section29)

• 2010 - 2015 :

  Directeur adjoint Laboratoire d’Ecologie Alpine, UMR CNRS 5553- Université Joseph Fourier-Grenoble 1

• 2015 :

  Habilitation à Diriger les Recherches (Université Grenoble-Alpes)

• 2009 :

  Chargé de Recherche CNRS (CR1), section 29, LECA Grenoble

• 2005 :

  Chargé de Recherche CNRS (CR2), section 29, LECA Grenoble

• 2003 :

  Senior Research Assistant (Liverpool School of Tropical Medicine, UK)

• 2003 :

  Qualification aux fonctions de Maître de Conférences (sections 66 et 67)

• 2002 :

  Doctorat en Biologie-Ecologie (Université Joseph Fourier, Grenoble 1)

Track record

My career focused on the evolutionary mechanisms associated with the adaptation of insects to their changing environment. I obtained a PhD in vector ecology by studying the chemical interactions between plants and aquatic arthropods. As a post-doctoral fellow at the Liverpool School of Tropical Medicine (LSTM, UK), my research activities focused on the characterization of molecular mechanisms underlying the adaptation of malaria mosquito vectors to chemical insecticides. In 2005, I was awarded a full Researcher position at CNRS. Since then, I coordinated the research activities of the mosquito group of the Ecology Laboratory of Grenoble, France. My research experience in studying the evolutionary bases of insecticide resistance in mosquitoes allowed me to obtain my ‘Habilitation à Diriger les Recherches’ (HDR) in 2015. I was awarded a CNRS Research Director position in 2022. The research activities of my research group are focused on three axes : i) elucidate the genetic bases of xenobiotic adaptation in mosquitoes transmitting human pathogens, ii) investigate the evolutionary trade-off associated with such adaptations and their consequences in terms of adaptive trajectories, and iii) develop innovative molecular tools to study the spatio-temporal dynamics of insecticide-resistance in the field and improve vector management strategies. Through a large collaborative network and the publication of more than 85 research publications, my group acquired an international renown in mosquito ecology and evolution with a unique expertise in mosquito genomics.

PhD mentoring

• 2021 - 2024 : Tiphaine BACOT : Bourse MESRI, Directeur, co-encadrant JM Bonneville.
  Genetic bases of insecticide resistance in the invasive tiger mosquito – From field monitoring to molecular diagnostics.
• 2018 - 2021 : Marius Gonse ZOH : Côte d’Ivoire, Thèse financée par Bayer, co-direction avec S Reynaud.
  Evolution expérimentale de la résistance du vecteur du paludisme africain Anopheles gambiae à une nouvelle formulation biocide.
• 2013 - 2015 : Frédéric FAUCON : Bourse MESRI, Directeur.
  Caractérisation des gènes impliqués dans la résistance métabolique aux insecticides pyrethrinoïdes chez les moustiques.
• 2011 - 2014 : Thérésia NKYA : Contrat doctoral FP7 EU AvecNet, Directeur, co-tutelle entre l’UGA et l’Univ du Kilimanjaro Tanzanie.
  Investigating selection pressures influencing pyrethroid resistance in major malaria vector in different environments in Tanzania.
• 2012 - 2014 : Sophie PRUD’HOMME : Bourse ENS, co-direction avec S Reynaud.
  Impact des polluants urbains sur la dynamique des populations de moustiques.
• 2008 - 2011 : Guillaume TETREAU : Bourse MESRI, co-direction avec L Després.
  Devenir et impact du bactério-insecticide Bacillus thuringiensis var israelensis dans les écosystèmes et mécanismes de résistance chez les moustiques.
• 2008 - 2011 : Muhammad ASAM RIAZ : Bourse HEC Pakistan, co-direction avec S Reynaud, co-tutelle entre l’UGA et le Pakistan.
  Mécanismes moléculaires de la résistance à l’insecticide néonicotinoïde imidaclopride chez le vecteur de la dengue Aedes aegypti.
• 2007 - 2011 : Rodolphe POUPARDIN : Bourse MESRI, co-direction avec S Reynaud.
  Interactions gènes-environnement chez les moustiques et impact des polluants sur la résistance aux insecticides.
• 2005 - 2009 : Margot PÂRIS : Bourse MESRI, co-encadrant avec L Després.
  Evolution de la résistance au bactério-insecticide Bti chez les moustiques.

Post-doc / Engineer mentoring

• 2025 - 2026 : Nawelle MALINGE : Assistant ingénieur UGA.
  Gestionnaire des insectariums tropicaux du LECA.
• 2021 - 2025 : Louis NADALIN : CDD Ingénieur d’étude, projet ANSES Tigerisk2 et Région ARA TigerWatch.
  Résistance aux insecticides pyréthrinoïdes chez les moustiques Aedes.
• 2019 - 2021 : Jordan TUTAGATA : CDD Assistant ingénieur, projets Bayer Fludora-Fusion et ANSES Tigerisk2.
  Résistance aux insecticides chez les vecteurs du paludisme Anopheles gambiae. Evolution expérimentale et biologie moléculaire.
• 2017 - 2019 : Julien CATTEL : Post-doc, projets Arbovec-Plus et EU ZikAlliance.
  Caractérisation de nouveaux marqueurs moléculaires pour détecter la résistance aux insecticides chimiques chez les moustiques vecteurs d’arboviroses.
• 2017 - 2018 : Marius Gonse ZOH : CDD Assistant ingénieur, projet Bayer Fludora-Fusion.
  Evolution expérimentale de la résistance du vecteur du paludisme africain Anopheles gambiae à une nouvelle formulation biocide.
• 2016 - 2019 : Claire DUROT : CDD Ingénieur d’étude.
  Project Manager du réseau WIN. Co-encadrement avec V. Corbel IRD MIVEGEC.
• 2015 - 2017 : Frédéric FAUCON : Post-doc, projets IMMI REACTING et ANSES REAGIR.
  Caractérisation des marqueurs génétiques de la résistance chez les moustiques vecteurs d’arbovirose par séquençage NGS.
• 2011 - 2013 : Idir AKHOUAYRI : Post-doc, projet EU FP7 AvecNet.
  Impact des polluants urbains et agricoles sur la résistance des vecteurs du paludisme africains aux insecticides chimiques.
• 2011 - 2012 : Myriam REGENT-KLOECKNER : CDD Ingénieur d’étude + ATER UGA.
  Résistance du moustique Aedes aegypti aux insecticide néonicotinoïdes.
• 2009 - 2013 : Alexia CHANDOR-PROUST : Post-doc, projets EU FP7 AvecNet et ANR Mosquito-env.
  Caractérisation biochimique des enzymes de détoxication impliquées dans la résistance aux insecticides chimiques chez les moustiques.

Main fundings

• 2025 : Tiger-Resist : Surveillance moléculaire de la résistance aux insecticides du moustique tigre dans la zone du Sud -est de l’Océan Indien – Conventions de recherche CIRAD/ARS de la Réunion - (coordinator) - 110 K€
• 2022 : EU H2020 MSCA INOVEC : A research and Innovation partnership for enhancing the surveillance and control of mosquito vectors of emerging arboviruses - (partner) - 30 K€ (1.5 M€)
• 2021 : ANR PRC : FBI : Fighting Bed Bugs Infectations - (partner) - 50 K€ (500 K€)
• 2019 : FLUDORA-FUSION+ : Résistance des vecteurs du paludisme africains à une nouvelle formulation biocide. Bayer - (coordinator) - 50 K€
• 2019 : TIGERISK2, SEST ANSES : Evaluation du risque de résistance aux insecticides chez le moustique tigre – Une approche prédictive combinant sélection expérimentale et marqueurs moléculaires - (coordinator) - 200 K€
• 2019 : TIGERWATCH, Région ARA : Résistance aux insecticides chez le moustique tigre en région Auvergne Rhône-Alpes. Mise en place d’un réseau sentinelle prédictif combinant des marqueurs phénotypiques et moléculaires - (coordinator) - 158 K€
• 2019 : WIN-RISE, ANR MRSEI : The Worldwide Insecticide resistance Network - Research and Innovation Staff Exchange project : A global partnership for tracking and combating insecticide resistance in mosquito vectors of emerging arboviruses - (partner) - 50 K€
• 2018 : AedesWGSEQ, internal call FP7 EU Infravec2 #2276 : Genomic amplifications associated with insecticide resistance in the dengue vector mosquito Aedes aegypti – from NGS to high-throughput diagnostic assays - (partner) - 60 K€
• 2017 : FLUDORA-FUSION : Etude de l’évolution de la résistance des vecteurs du paludisme africains à une nouvelle formulation biocide. Bayer - (co-coordinator) - 265 K€
• 2016 : ARBOVEC-PLUS, US Naval Medical Research Center - Asia : Insecticide resistance in dengue vectors, resistance mapping and identification of novel molecular markers in Lao PDR - (partner) - 50 K€ (220 K€)
• 2016 : ZIKALLIANCE EU H2020 : A Global Alliance For Zika Virus Control And Prevention - (partner) - 88 K€ (10 M€)
• 2015 : WIN, OMS/TDR : The Worldwide insecticide resistance network – an international network to combat mosquito vectors of arboviruses - (co-coordinator) - 200 K€
• 2014 : REAGIR, ANSES : Résistance aux pyréthrinoïdes chez Aedes aegypti : évaluation de nouveaux candidats insecticides et étude du phénomène de réversion - (partner) - 55 K€ (200 K€)
• 2014 : ANOPEST, Wellcome Trust : Assessment of the role of non-insecticide agrochemicals in selecting resistance to insecticides in the principal malaria vector Anopheles gambiae - (partner) - 560 K€
• 2011 : EU FP7 Africa AvecNet : Controlling malaria by hitting the vector : new or improved vector control tools - (partner) - 550 K€ (12M€)
• 2009 : ANR DIBBECO : Devenir et impacts du bactério-insecticide Bti dans les ecosystèmes - (partner) - 50 K€ (300 K€)
• 2008 : ANR MOSQUITO-ENV : Interactions gènes-environnement et résistance aux insecticides chez les moustiques - (coordinator) - 200 K€
• 2008 : Région Rhône-Alpes CIBLE : Résistance des moustiques aux bactério-insecticide Bacillus thuringiensis - (partner) - 47 K€ (200 K€)

86 publications (6321 external citations, h-index 38, source WoK)

2025

• Bacot T, Bonneville JM, Lacroix V, Oberbach P, Gaude T, Nadalin L, Laporte F, Habchi-Hanriot N, Dupuy G, Czeher C, Fontain MC, Boyer F, David JP. Metabolic resistance of the tiger mosquito to pyrethroid insecticides in La Reunion Island likely results from local adaptation. 2025, BIORXIV/2025/668844 (preprint, under revision at Genome Biology and Evolution). https://doi.org/10.1101/2025.08.06.668844

2024

• Bacot T, Haberkorn C, Guilliet J, Cattel J, Kefi M, Nadalin L, Filee J, Boyer F, Gaude T, Laporte F, Tutagata J, Vontas J, IDusfour I, Bonneville JM, David JP. A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti, Peer Community Journal, 4 : e110. doi.org/10.24072/pcjournal.497. Reviewed and recommended by PCI Evolutionary Biology https://doi.org/10.24072/pci.evolbiol.100790
• Almera L, Melo costa M, Amalvict R, Guilliet J, Dusfour I, David JP, Corbel V. Potential of MALDI-TOF MS biotyping to detect deltamethrin resistance in the dengue vector Aedes aegypti. Plos One. 2024,19(5) : e0303027. https://doi.org/10.1371/journal.pone.0303027
• Sadia CG, Bonneville JM, Zoh MG, Fodjo BK, Kouadio FPA, Oyon SK, Benjamin KG, Beatrice AGA, Reynaud S, David JP, Mouhamadou CS. The impact of agrochemical pollutant mixtures on the selection of insecticide resistance in the malaria vector Anopheles gambiae : insights from experimental evolution and transcriptomics. Malaria Journal 2024, 23(1):69. https://doi.org/10.1186/s12936-023-04791-0

2023

• Haberkorn C, David JP, Henri H, Delpuech JM, Lasseur R, Vavre F, Varaldi J. A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius. Evolutionary Applications. 2023, 16(5):1012-1028. https://doi.org/10.1111/eva.13550.
• Zoh MG, Bonneville JM, Laporte F, Tutagata J, Sadia CG, Fodjo BK, Mouhamadou CS, McBeath J, Schmitt F, Horstmann S, Reynaud S, David JP. Deltamethrin and transfluthrin select for distinct transcriptomic responses in the malaria vector Anopheles gambiae. Malaria Journal, 2023 Sep 4 ;22(1):256. https://doi.org/10.1186/s12936-023-04673-5.
• Devillers J, David JP, Barrès B, Alout H , Bruno Lapied B, Chouin S, Dusfour I, Billault C , Mekki F, Attig I, Corbel V. Integrated Plan of Insecticide Resistance Surveillance in Mosquito Vectors in France. Insects. 2023, 12 ;14(5):457. https://doi.org/10.3390/insects14050457.

2022

• Zoh MG, Tutagata, Fodjo KB, Chouaïbou M, Sadia CG, McBeath J, Schmitt F, Horstmann S, David JP, Reynaud S. Exposure of Anopheles gambiae larvae to a sub-lethal dose of an agrochemical mixture induces tolerance to Fludora® Fusion and to its neonicotinoid component in adults – Aquatic Toxicology, 2022, 248:106181. https://doi.org/10.1016/j.aquatox.2022.106181
• Sherpa S, Tutagata J, Gaude T, Laporte F, Kasai S, Ishak IH, Guo X, Shin J, Boyer S, Marcombe S, Chareonviriyaphap T, David JP, Després L. Genomic shifts, phenotypic clines and fitness costs associated with cold-tolerance in the Asian tiger mosquito- Molecular Biology and Evolution, 2022, 39(5) : msac104. https://academic.oup.com/mbe/article/39/5/msac104/6586214
• Kampango A, Hocke FE, Hansson H, Furu P, Haji KA, David JP, Konradsen F, Saleh F, Weldon CW, Schiøler KL, Alifrangis M. High DDT resistance without apparent association to kdr and Glutathione-S-transferase (GST) gene mutations in Aedes aegypti population at hotel compounds in Zanzibar- Plos Neglected Tropical Diseases, 2022, 16(5). https://doi.org/10.1371/journal.pntd.001035

2021

• Zoh MG, Bonneville JM, Tutagata J, Laporte F, Fodjo BK, Mouhamadou CS, Sadia CG, McBeath J, Schmitt F, Horstmann S, Reynaud S, David JP. Experimental evolution supports the potential of neonicotinoid-pyrethroid combination for managing insecticide resistance in malaria vectors. Scientific Reports, 2021, 11:1950. https://doi.org/10.1038/s41598-021-99061-x
• Zoh MG , Gaude T, Prud’homme SM, Riaz MA , David JP*, Reynaud S*. Molecular bases of P450-mediated resistance to the neonicotinoid insecticide imidacloprid in the mosquito Ae. aegypti. Aquatic Toxicology 2021 Jul ;236:105860. https://doi.org/10.1016/j.aquatox.2021.105860. (*co-last authors).
• Cattel J, Minier M, Habchi-Hanriot N, Pol M, Faucon F, Gaude T, Gaborit P, Issaly J, Ferrero E, Chandre F, Pocquet N, David JP*, Dusfourd I*. Impact of selection regime and introgression on deltamethrin resistance in the arbovirus vector Aedes aegypti – a comparative study between contrasted situations in New Caledonia and French Guiana. Pest Management Science 2021. https://doi.org/10.1002/ps.6602. Online ahead of print. (* co-last authors).

2020

• Cattel J, Haberkorn C, Laporte F, Gaude T, Cumer T, Renaud J, Sutherland I W, Hertz J C, Bonneville JB, Arnaud V, Fustec B, Boyer S, Marcombe S and David JP. A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti : from genomic characterization to high-throughput field detection. Evolutionary Applications 2020 ;00:1–14. https://doi.org/10.1111/eva.13177
• Cattel J, Haberkorn C, Laporte F, Gaude T, Cumer ., Renaud J, Sutherland IW, Hertz J., Bonneville JM, Arnaud V, Noûs C, Fustec B, Boyer S, Marcombe S, David JP. A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti : from genomic characterization to high-throughput field detection. bioRxiv, 2020.06.08.139741, ver. 4 peer-reviewed and recommended by PCI Evolutionary Biology 2020. https://doi.org/10.1101/2020.06.08.139741

2019

• Marcombe S, Fustec B, Cattel J, Chonephetsarath S, Thammavong P, Phommavan N, David JP, Corbel V, Sutherland IW, Hertz JC and Brey PT. Distribution of insecticide resistance and mechanisms involved in the arbovirus vector Aedes aegypti in Laos and implication for vector control. Plos Neglected Tropical Diseases 2019, 13(12):e0007852. https://doi.org/10.1371/journal.pntd.0007852
• Dusfour I, Vontas J, David JP, Weetman D, Fonseca D, Raghavendraa K, Corbel V, Coulibaly M, Martins A, Chandre F. Management of insecticide resistance in the major Aedes vectors of arboviruses : advances and challenges. Plos Neglected Tropical Diseases 2019, 13(10):e0007615. https://doi.org/10.1371/journal.pntd.0007615
• Cattel J, Faucon F, Le Peron B, Sherpa S, Monchal M, Grillet L, Gaude T, Laporte F, Dusfour I, Reynaud S, David JP. Combining genetic crosses and pool targeted DNA-seq for untangling genomic variations associated with resistance to multiple insecticides in the mosquito Aedes aegypti. Evolutionary Applications. 2019,13(2):303-317. https://doi.org/10.1111/eva.12867
• Corbel V, Durot C, Achee NL, Chandre F, Coulibaly MB, David JP, Devine GJ, Dusfour I, Fonseca DM, Griego J, Juntarajumnong W, Lenhart A, Kasai S, Martins AJ, Moyes C, Ng LC, Pinto J, Pompon JF, Muller P, Raghavendra K, Roiz D, Vatandoost H, Vontas J, Weetman D. Second WIN International Conference on "Integrated approaches and innovative tools for combating insecticide resistance in vectors of arboviruses", October 2018, Singapore. Parasites & vectors. 2019, 12. https://doi.org/10.1186/s13071-019-3591-8
• Achee N, Grieco JP, Vatandoost H, Seixas G, Pinto J, Ching L, Martins AJ, Juntarajumnong W, Corbel V, Gouagna C, David JP, Logan J, Osborn J, Marois E, Devine GJ, Vontas J. Alternative Strategies for Arbovirus Control. Plos Neglected Tropical Diseases 2019, 13(1), e0006822. https://doi.org/10.1371/journal.pntd.0006822

2018

• Prud’homme S, Renault D, David JP, Renaud S. Multiscale Approach to Deciphering the Molecular Mechanisms Involved in the Direct and Intergenerational Effect of Ibuprofen on Mosquito Aedes aegypti.Environmental Science and Technology 2018, 52 (14),7937-7950. https://doi.org/10.1021/acs.est.8b00988

2017

• Moyes C, Vontas J, Martins AJ, Ching Ng L, Koou SY, Dusfour I, Raghavendra K, Pinto J, Corbel V, David JP, Weetman D. Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans. PLoS Neglected Tropical Diseases 2017, 11(7):e0005625. https://doi.org/10.1371/journal.pntd.0005625 (review)
• Prud’homme SM, Chaumot A, Cassar E, David JP, Reynaud S. Impact of micropollutants on the life-history traits of the mosquito Aedes aegypti : On the relevance of transgenerational studies. Environmental Pollution. 2017, 220:242-54. https://doi.org/10.1016/j.envpol.2016.09.056
• Goindin D, Delannay C, Gelasse A, Ramdini C, Gaude T, Faucon F, David JP, Gustave J, Vega-Rua A, Fouque F. Levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands (French West Indies). Infectious Diseases of Poverty. 2017, 6. https://doi.org/10.1186/S0249-017-0254-x
• Faucon F, Gaude T, Dusfour I, Navratil V, Corbel V, Juntarajumnong W, Girod R, Poupardin R, Boyer F, Reynaud S, David JP. In the hunt for genomic markers of metabolic resistance to pyrethroids in the mosquito Aedes aegypti : An integrated next-generation sequencing approach. Plos Neglected Tropical Diseases. 2017, 11(4). https://doi.org/10.1371/journal.pntd.0005526
• Corbel V, Fonseca DM, Weetman D, Pinto J, Achee NL, Chandre F, Coulibaly MB, Dusfour I, Grieco J, Juntarajumnong W, Lenhart A, Martins AJ, Moyes C, Ng LC, Raghavendra K, Vatandoost H, Vontas J, Muller P, Kasai S, Fouque F, Velayudhan R, Durot C, David JP. International workshop on insecticide resistance in vectors of arboviruses, December 2016, Rio de Janeiro, Brazil. Parasites & Vectors. 2017, 10. https://doi.org/10.1186/s13071-017-2224-3

2016

• Corbel V, Achee NL, Chandre F, Coulibaly MB, Dusfour I, Fonseca DM, Grieco J, Juntarajumnong W, Lenhart A, Martins AJ, Moyes C, Ng LC, Pinto J, Raghavendra K, Vatandoost H, Vontas J, Weetman D, Fouque F, Velayudhan R, David JP. Tracking Insecticide Resistance in Mosquito Vectors of Arboviruses : The Worldwide Insecticide resistance Network (WIN). Plos Neglected Tropical Diseases. 2016, 10(12). https://doi.org/10.1371/journal.pntd.0005054
• Chouaibou MS, Fodjo BK, Fokou G, Allassane OF, Koudou BG, David JP, Antonio-Nkondjio C, Ranson H, Bonfoh B. Influence of the agrochemicals used for rice and vegetable cultivation on insecticide resistance in malaria vectors in southern Cote d’Ivoire. Malaria Journal. 2016, 15. https://doi.org/10.1186/s12936-016-1481-5

2015

• Faucon F, Dusfour I, Gaude T, Navratil V, Boyer F, Chandre F, Sirisopa P, Thanispong K, Juntarajumnong W, Poupardin R, Chareonviriyaphap T, Girod R, Corbel V, Reynaud S, David JP. Identifying genomic changes associated with insecticide resistance in the dengue mosquito Aedes aegypti by deep targeted sequencing. Genome Research. 2015, 25(9):1347-59. https://doi.org/10.1101/gr.189225.115

2014

• Nkya TE, Poupardin R, Laporte F, Akhouayri I, Mosha F, Magesa S, Kisinza W, David JP. Impact of agriculture on the selection of insecticide resistance in the malaria vector Anopheles gambiae : a multigenerational study in controlled conditions. Parasites & Vectors. 2014, 7. https://doi.org/10.1186/s13071-014-0480-z
• Nkya TE, Akhouayri I, Poupardin R, Batengana B, Mosha F, Magesa S, Kisinza W, David JP. Insecticide resistance mechanisms associated with different environments in the malaria vector Anopheles gambiae : a case study in Tanzania. Malaria Journal. 2014, 13. https://doi.org/10.1186/1475-2875-13-28
• Duchet C, Tetreau G, Marie A, Rey D, Besnard G, Perrin Y, Paris M, David JP, Lagneau C, Despres L. Persistence and Recycling of Bioinsecticidal Bacillus thuringiensis subsp israelensis Spores in Contrasting Environments : Evidence from Field Monitoring and Laboratory Experiments. Microbial Ecology. 2014, 67(3):576-86. https://doi.org/10.1007/s00248-013-0360-7
• Despres L, Stalinski R, Tetreau G, Paris M, Bonin A, Navratil V, Reynaud S, David JP. Gene expression patterns and sequence polymorphisms associated with mosquito resistance to Bacillus thuringiensis israelensis toxins. BMC Genomics. 2014, 15. https://doi.org/10.1186/1471-2164-15-926
• Despres L, Stalinski R, Faucon F, Navratil V, Viari A, Paris M, Tetreau G, Poupardin R, Riaz MA, Bonin A, Reynaud S, David JP. Chemical and biological insecticides select distinct gene expression patterns in Aedes aegypti mosquito. Biology Letters. 2014, 10(12). https://doi.org/10.1098/rsbl.2014.0716
• David JP, Faucon F, Chandor-Proust A, Poupardin R, Riaz MA, Bonin A, Navratil V, Reynaud S. Comparative analysis of response to selection with three insecticides in the dengue mosquito Aedes aegypti using mRNA sequencing. BMC Genomics. 2014, 15. https://doi.org/10.1186/1471-2164-15-174

2013

• Tetreau G, Stalinski R, David JP, Despres L. Increase in larval gut proteolytic activities and Bti resistance in the dengue fever mosquito. Archives of Insect Biochemistry and Physiology. 2013, 82(2):71-83. https://doi.org/10.1002/arch.21076
• Tetreau G, Stalinski R, David JP, Despres L. Monitoring resistance to Bacillus thuringiensis subsp israelensis in the field by performing bioassays with each Cry toxin separately. Memorias Do Instituto Oswaldo Cruz. 2013, 108(7):894-+. https://doi.org/10.1590/0074-0276130155
• Riaz MA, Chandor-Proust A, Dauphin-Villemant C, Poupardin R, Jones CM, Strode C, Regent-Kloeckner M, David JP, Reynaud S. Molecular mechanisms associated with increased tolerance to the neonicotinoid insecticide imidacloprid in the dengue vector Aedes aegypti. Aquatic Toxicology. 2013, 126:326-37. https://doi.org/10.1016/j.aquatox.2012.09.010
• Pondeville E, David JP, Guittard E, Maria A, Jacques J-C, Ranson H, Bourgouin C, Dauphin-Villemant C. Microarray and RNAi Analysis of P450s in Anopheles gambiae Male and Female Steroidogenic Tissues : CYP307A1 Is Required for Ecdysteroid Synthesis. Plos One. 2013, 8(12). https://doi.org/10.1371/journal.pone.0079861
• Paris M, Marcombe S, Coissac E, Corbel V, David JP, Despres L. Investigating the genetics of Bti resistance using mRNA tag sequencing : application on laboratory strains and natural populations of the dengue vector Aedes aegypti. Evolutionary Applications. 2013, 6(7):1012-27. https://doi.org/10.1111/eva.12082
• Nkya TE, Akhouayri I, Kisinza W, David JP. Impact of environment on mosquito response to pyrethroid insecticides : Facts, evidences and prospects. Insect Biochemistry and Molecular Biology. 2013, 43(4):407-16. https://doi.org/10.1016/j.ibmb.2012.10.006 (Review)
• Marcombe S, Paris M, Paupy C, Bringuier C, Yebakima A, Chandre F, David JP, Corbel V, Despres L. Insecticide-Driven Patterns of Genetic Variation in the Dengue Vector Aedes aegypti in Martinique Island. Plos One. 2013, 8(10). https://doi.org/10.1371/journal.pone.0077857
• David JP, Poupardin R, Riaz MA, Chandor-Proust A, Faucon F, Navratil V, Reynaud S. transcriptomechanges associated to adaptation to insecticides in the dengue mosquito Aedes aegypti. New insights from high-throughput RNA sequencing. Pathogens and Global Health. 2013, 107(8):434-5.
• Chandor-Proust A, Bibby J, Regent-Kloeckner M, Roux J, Guittard-Crilat E, Poupardin R, Riaz MA, Paine M, Dauphin-Villemant C, Reynaud S, David JP. The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling. Biochemical Journal. 2013, 455:75-85. https://doi.org/10.1042/bj20130577
• David JP, Ismail HM, Chandor-Proust A, Paine MJI. Role of cytochrome P450s in insecticide resistance : impact on the control of mosquito-borne diseases and use of insecticides on Earth. Philosophical Transactions of the Royal Society B-Biological Sciences. 2013, 368(1612). https://doi.org/10.1098/rstb.2012.0429 (Review)

2012

• Tetreau G, Stalinski R, Kersusan D, Veyrenc S, David JP, Reynaud S, Despres L. Decreased Toxicity of Bacillus thuringiensis subsp israelensis to Mosquito Larvae after Contact with Leaf Litter. Applied and Environmental Microbiology. 2012, 78(15):5189-95. https://doi.org/10.1128/aem.00903-12
• Tetreau G, Bayyareddy K, Jones CM, Stalinski R, Riaz MA, Paris M, David JP, Adang MJ, Despres L. Larval midgut modifications associated with Bti resistance in the yellow fever mosquito using proteomic and transcriptomic approaches. Bmc Genomics. 2012, 13. https://doi.org/10.1186/1471-2164-13-248
• Tetreau G, Alessi M, Veyrenc S, Perigon S, David JP, Reynaud S, Despres L. Fate of Bacillus thuringiensis subsp israelensis in the Field : Evidence for Spore Recycling and Differential Persistence of Toxins in Leaf Litter. Applied and Environmental Microbiology. 2012, 78(23):8362-7. https://doi.org/10.1128/aem.02088-12
• Poupardin R, Riaz MA, Jones CM, Chandor-Proust A, Reynaud S, David JP. Do pollutants affect insecticide-driven gene selection in mosquitoes ? Experimental evidence from transcriptomics. Aquatic Toxicology. 2012, 114:49-57. https://doi.org/10.1016/j.aquatox.2012.02.001
• Paris M, Melodelima C, Coissac E, Tetreau G, Reynaud S, David JP, Despres L. Transcription profiling of resistance to Bti toxins in the mosquito Aedes aegypti using next-generation sequencing. Journal of Invertebrate Pathology. 2012, 109(2):201-8. https://doi.org/10.1016/j.jip.2011.11.004
• Marcombe S, Mathieu RB, Pocquet N, Riaz M-A, Poupardin R, Selior S, Darriet F, Reynaud S, Yebakima A, Corbel V, David JP, Chandre F. Insecticide Resistance in the Dengue Vector Aedes aegypti from Martinique : Distribution, Mechanisms and Relations with Environmental Factors. Plos One. 2012, 7(2). https://doi.org/10.1371/journal.pone.0030989

2011

• Paris M, Tetreau G, Laurent F, Lelu M, Despres L, David JP. Persistence of Bacillus thuringiensis israelensis (Bti) in the environment induces resistance to multiple Bti toxins in mosquitoes. Pest Management Science. 2011, 67(1):122-8. https://doi.org/10.1002/ps.2046
• Paris M, David JP, Despres L. Fitness costs of resistance to Bti toxins in the dengue vector Aedes aegypti. Ecotoxicology. 2011, 20(6):1184-94. https://doi.org/10.1007/s10646-011-0663-8

2010

• Poupardin R, Riaz MA, Vontas J, David JP, Reynaud S. Transcription profiling of eleven cytochrome P450s potentially involved in xenobiotic metabolism in the mosquito Aedes aegypti. Insect Molecular Biology. 2010, 19(2):185-93. https://doi.org/10.1111/j.1365-2583.2009.00967.x
• Paris M, Boyer S, Bonin A, Collado A, David JP, Despres L. Genome scan in the mosquito Aedes rusticus : population structure and detection of positive selection after insecticide treatment. Molecular Ecology. 2010, 19(2):325-37. https://doi.org/10.1111/j.1365-294X.2009.04437.x
• David JP, Coissac E, Melodelima C, Poupardin R, Riaz MA, Chandor-Proust A, Reynaud S. Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology. BMC Genomics. 2010, 11. https://doi.org/10.1186/1471-2164-11-216

2009

• Riaz MA, Poupardin R, Reynaud S, Strode C, Ranson H, David JP. Impact of glyphosate and benzo a pyrene on the tolerance of mosquito larvae to chemical insecticides. Role of detoxification genes in response to xenobiotics. Aquatic Toxicology. 2009, 93(1):61-9. https://doi.org/10.1016/j.aquatox.2009.03.005
• Marcombe S, Poupardin R, Darriet F, Reynaud S, Bonnet J, Strode C, Brengues C, Yebakima A, Ranson H, Corbel V, David JP. Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti : a case study in Martinique Island (French West Indies). BMC Genomics. 2009, 10. https://doi.org/10.1186/1471-2164-10-494
• Bonin A, Paris M, Tetreau G, David JP, Despres L. Candidate genes revealed by a genome scan for mosquito resistance to a bacterial insecticide : sequence and gene expression variations. BMC Genomics. 2009, 10. https://doi.org/10.1186/1471-2164-10-551

2008

• Strode C, Wondji CS, David JP, Hawkes NJ, Lumjuan N, Nelson DR, Drane DR, Karunaratne SHPP, Hemingway J, Black WC, Ranson H. Genomic analysis of detoxification genes in the mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology. 2008, 38(1):113-23. https://doi.org/10.1016/j.ibmb.2007.09.007
• Poupardin R, Reynaud S, Strode C, Ranson H, Vontas J, David JP. Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti : Impact on larval tolerance to chemical insecticides. Insect Biochemistry and Molecular Biology. 2008, 38(5):540-51. https://doi.org/10.1016/j.ibmb.2008.01.004
• McLaughlin LA, Niazi U, Bibby J, David JP, Vontas J, Hemingway J, Ranson H, Sutcliffe MJ, Paine MJI. Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2. Insect Molecular Biology. 2008, 17(2):125-35. https://doi.org/10.1111/j.1365-2583.2007.00788.x
• Marcombe S, Poupardin R, Darriet F, Strode C, Yebakima A, Ranson H, David JP, Corbel V. Identification of metabolic insecticide resistance genes in Aedes aegypti from Martinique (French West Indies) : from genotypes to phenotypes. American Journal of Tropical Medicine and Hygiene. 2008, 79(6):69-.
• Bonin A, Paris M, Despres L, Tetreau G, David JP, Kilian A. A MITE-based genotyping method to reveal hundreds of DNA polymorphisms in an animal genome after a few generations of artificial selection. BMC Genomics. 2008, 9. https://doi.org/10.1186/1471-2164-9-459

2007

• Despres L*, David JP*, Gallet, C. The evolutionary ecology of insect resistance to plant chemicals. Trends in Ecology and Evolution. 2007, 22(6):298-307. (*equal contribution, co-first author)
  Vontas J, David JP, Nikou D, Hemingway J, Christophides GK, Louis C, Ranson H. Transcriptional analysis of insecticide resistance in Anopheles stephensi using cross-species microarray hybridization. Insect Molecular Biology. 2007, 16(3):315-24. https://doi.org/10.1111/j.1365-2583.2007.00728.x

2006

• David JP, Boyer S, Mesneau A, Ball A, Ranson H, Dauphin-Villemant C. Involvement of cytochrome P450 monooxygenases in the response of mosquito larvae to dietary plant xenobiotics. Insect Biochemistry and Molecular Biology. 2006, 36(5):410-20. https://doi.org/10.1016/j.ibmb.2006.02.004
• Boyer S, David JP, Rey D, Lemperiere G, Ravanel P. Response of Aedes aegypti (Diptera : Culicidae) larvae to three xenobiotic exposures : Larval tolerance and detoxifying enzyme activities. Environmental Toxicology and Chemistry. 2006, 25(2):470-6. https://doi.org/10.1897/05-267r2.1

2005

• Vontas J, Blass C, Koutsos AC, David JP, Kafatos FC, Louis C, Hemingway J, Christophides GK, Ranson H. Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure. Insect Molecular Biology. 2005, 14(5):509-21. https://doi.org/10.1111/j.1365-2583.2005.00582.x
• Ranson H, David JP, Strode C, Muller P, Vontas J. Progress towards a specific microarray for detecting insecticide resistance in field populations of malaria vectors. American Journal of Tropical Medicine and Hygiene. 2005, 73(6):205-6.
• David JP, Strode C, Vontas J, Nikou D, Vaughan A, Pignatelli PM, Louis C, Hemingway J, Ranson H. The Anopheles gambiae detoxification chip : A highly specific microarray to study metabolic-based insecticide resistance in malaria vectors. Proceedings of the National Academy of Sciences of the United States of America. 2005, 102(11):4080-4. https://doi.org/10.1073/pnas.0409348102

2003

• David JP, Dauphin-Villemant C, Mesneau A, Meyran JC. Molecular approach to aquatic environmental bioreporting : differential response to environmental inducers of cytochrome P450 monooxygenase genes in the detritivorous subalpine planktonic Crustacea, Daphnia pulex. Molecular Ecology. 2003, 12(9):2473-81. https://doi.org/10.1046/j.1365-294x.2003.01913.x
• Rey D, David JP, Meyran JC. Factors influencing the toxicity of xenobiotics against larval mosquitoes. Comptes Rendus Biologies. 2003, 326(3):317-27. https://doi.org/10.1016/s1631-0691(03)00076-3
• David JP, Tilquin M, Rey D, Ravanel P, Meyran JC. Mosquito larval consumption of toxic arborescent leaf-litter, and its biocontrol potential. Medical and Veterinary Entomology. 2003, 17(2):151-7. https://doi.org/10.1046/j.1365-2915.2003.00432.x
• David JP, Huber K, Failloux AB, Rey D, Meyran JC. The role of environment in shaping the genetic diversity of the subalpine mosquito, Aedes rusticus (Diptera, Culicidae). Molecular Ecology. 2003, 12(7):1951-61. https://doi.org/10.1046/j.1365-294X.2003.01870.x

2002

• David JP, Rey D, Cuany A, Bride JM, Meyran JC. Larvicidal properties of decomposed leaf litter in the subalpine mosquito breeding sites. Environmental Toxicology and Chemistry. 2002, 21(1):62-6. https://doi.org/10.1897/1551-5028(2002)021<0062:lpodll>2.0.co, 2
• David JP, Ferran A, Gambier J, Meyran JC. Taste sensitivity of detritivorous mosquito larvae to decomposed leaf litter. Journal of Chemical Ecology. 2002, 28(5):983-95. https://doi.org/10.1023/a:1015257700992

2001

• Rey D, David JP, Besnard G, Jullien JL, Lagneau C, Meyran JC. Comparative sensitivity of larval mosquitoes to vegetable polyphenols versus conventional insecticides. Entomologia Experimentalis Et Applicata. 2001, 98(3):361-7. https://doi.org/10.1046/j.1570-7458.2001.00793.x
• Pautou MP, Rey D, David JP, Meyran JC. Toxicity of vegetable tannins on crustacea associated with alpine mosquito breeding sites (vol 47, pg 334, 2000). Ecotoxicology and Environmental Safety. 2001, 49(1):99-.
• David JP, Rey D, Meyran JC, Marigo G. Involvement of ligninlike compounds in toxicity of dietary alder leaf litter against mosquito larvae. Journal of Chemical Ecology. 2001, 27(1):161-74. https://doi.org/10.1023/a:1005632403561

2000

• Rey D, David JP, Martins D, Pautou MP, Long A, Marigo G, Meyran JC. Role of vegetable tannins in habitat selection among mosquito communities from the Alpine hydrosystems. Comptes Rendus De L Academie Des Sciences Serie Iii-Sciences De La Vie-Life Sciences. 2000, 323(4):391-8. dhttps://doi.org/10.1016/s0764-4469(00)00136-0
• Rey D, David JP, Cuany A, Amichot M, Meyran JC. Differential sensitivity to vegetable tannins in planktonic crustacea from alpine mosquito breeding sites. Pesticide Biochemistry and Physiology. 2000, 67(2):103-13. https://doi.org/10.1006/pest.2000.2482
• Pautou MP, Rey D, David JP, Meyran JC. Toxicity of vegetable tannins on Crustacea associated with alpine mosquito breeding sites. Ecotoxicology and Environmental Safety. 2000, 47(3):323-32. https://doi.org/10.1006/eesa.2000.1952
• David JP, Rey D, Pautou MP, Meyran JC. Differential toxicity of leaf litter to dipteran larvae of mosquito developmental sites. Journal of Invertebrate Pathology. 2000, 75(1):9-18. https://doi.org/10.1006/jipa.1999.4886
• David JP, Rey D, Marigo G, Meyran JC. Larvicidal effect of a cell-wall fraction isolated from alder decaying leaves. Journal of Chemical Ecology. 2000, 26(4):901-13. https://doi.org/10.1023/a:1005456124756
• David JP, Rey D, Cuany A, Amichot M, Meyran JC. Comparative ability to detoxify alder leaf litter in field larval mosquito collections. Archives of Insect Biochemistry and Physiology. 2000, 44(4):143-50. https://doi.org/10.1002/1520-6327(200008)44:4<143::aid-arch1>3.0.co ;2-a